Cash and jewellery were stolen from a house in Stotfold on Tuesday (October 8).
The burglary took place between 10.45pm and 10.55pm at a property in Hitchin Road.
Four burglars forced open a side door and entered the house.
They searched the bedrooms and stole a substantial amount of gold jewellery as well as large sums of cash in different denominations.
The offenders were then seen fleeing the property as the victim returned home.
Detective Constable Lynn Adams, who is investigating the incident, is keen to hear from anyone who was in the area at the time and may have seen anything suspicious.
Anyone with information can contact DC Adams, in confidence, on 01234 275142 or on the 101 number.