A safe was broken into at an address in Shefford Road, Meppershall.
The incident happened between 1pm on Friday (14 August) and 8am on Tuesday (18 August).
A large quantity of money was stolen as well as a gold watch and a gold-coloured necklace which had a medical pendant attached to it.
PC Lisa Lee, investigating, said: “The necklace in particular is quite distinctive as it has an engraved medical pendant attached to it.”
Anyone with information is asked to contact PC Lee on 101, text 07786 200 011, or call Crimestoppers, anonymously, on 0800 555 111.